IS SURVIVIN LEVEL IDENTICAL BETWEEN ADENOMAS OF PROXIMAL AND DISTAL COLON?

نویسندگان

چکیده

Objectives: Considerable differences are known between proximal and distal colon, these include embryological, anatomical, histological, biochemical, physiological characteristics. Above mentioned distinctions may influence development of variable clinico-morphological entities. Multifunctional antiapoptotic protein survivin participates in regulation cell cycle, apoptotic cascades, stimulates angiogenesis. Material methods: We assessed immunohistochemically expression pattern a panel 243 colon adenomas to determine its association with localization. In each section, subcellular compartmentalization intensity immunoreaction were evaluated. Results: Survivin was expressed 190 cases (78.2%). Statistical analysis confirmed significant correlation localization adenomas. Conclusions: Taking into account unique features survivin, proximally sided adenomas, left right we suppose that level contribute higher proliferative phenotype

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ژورنال

عنوان ژورنال: Revista Argentina de Anatomía Clínica

سال: 2022

ISSN: ['1852-8023']

DOI: https://doi.org/10.31051/1852.8023.v14.n2.37625